Modular Design

Autoloader module, which has a worktable with four 48-position vial trays. The trays are standard footprint, and easily integrated with existing robotics systems. It has a robotic arm which automatically picks up and move vials to the sample position of the Titrator module.

At the front of the Autoloader module is a built-in ultrasonic bath, which can be automatically used to aid the dissolution of poorly soluble compounds.

Dispenser module, which houses the precision micro dispensers for adding water, solvents and acid/base titrants from the reagent bottles stored in the drawer underneath. The instrument can have up to 6 different cosolvents loaded simultaneously (Methanol, Ethanol, DMSO, Acetonitrile, Dioxane, DMF, THF and others). Also contained within this module is a UV/Vis spectrometer and light source, which is connected to a fibre optic dip probe. This provides the same high quality UV/Vis spectroscopic functionality as our well established D-PAS system for the GLpKa.

Titrator module, which features a moving arm with the assay probes attached – pH electrode, UV dip probe, overhead stirrer, temperature sensor and capillaries for reagent addition. All of these probes have been miniaturised to fit into 1ml solution volumes. There is a row of buffer and wash positions used for automatically calibrating and cleaning the probes, including a flowing water wash which cleans the electrode with fresh water after each experiment. At the front of the Titrator module is the sample position, which is temperature controlled with a Peltier device (fully controlled by computer), and an additional turbidity sensing device. This is the position where the titration for pKa, logP/D or solubility is performed.